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In vitro research have shown that leptin also inhibits testosterone generation immediately at the testes. A range of epidemiological experiments have found that bone mineral density in the ageing male population is positively associated with endogenous androgen concentrations (Murphy et al 1993 Ongphiphadhanakul et al 1995 Rucker et al 2004). Testosterone stages in young guys have been proven to correlate with bone dimension, indicating a part in resolve of peak bone mass and safety from long term osteoporosis (Lorentzon et al 2005). Male hypogonadism has been shown to be a risk aspect for hip fracture (Jackson et al 1992) and a recent research confirmed a large prevalence of hypogonadism in a group of male patients with ordinary age 75 yrs presenting with small trauma fractures compared to stroke victims who acted as controls (Leifke et al 2005). Estrogen is a very well known determinant of bone density in gals and some investigators have located serum estrogen to be a strong determinant of male bone density (Khosla et al 1998 Khosla et al 2001). Serum estrogen was also found to correlate better than testosterone with peak bone mass (Khosla et al 2001) but this is in contradiction of a additional current examine demonstrating a adverse correlation of estrogen with peak bone dimensions (Lorentzon et al 2005). Men with aromatase deficiency (Carani et al 1997) or Best Free Sex Videos defunctioning estrogen receptor mutations (Smith et al 1994) have been discovered to have abnormally reduced bone density despite usual or significant testosterone levels which even further emphasizes the essential affect of estrogen on male bone density.

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